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ea0011p30 | Bone | ECE2006

Asymptomatic primary hyperparathyroidism: preliminary results of a prospetive randomized study on the effect of parathyroidectomy

Ambrogini E , Cianferotti L , Vignali E , Cetani F , Viccica G , Picone A , Miccoli P , Pinchera A , Marcocci C

Aim of this 2-year, prospective, randomized study is to compare the effect of parathyroidectomy (PTX) vs no treatment in patients with asymptomatic primary hyperparathyroidism (PHPT), who didnt meet the 1991 NIH criteria for surgery. The study was approved by our local Ethical Committee. The primary endpoint was the change in lumbar spine bone mineral density (BMD); secondary endpoints were BMD changes at femur and distal radius, markers of bone turnover, quality ...

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ea0011p535 | Endocrine tumours and neoplasia | ECE2006

Genetic analyses of familial isolated primary hyperparathyroidism: implications for clinical assessment and surgical management

Marcocci C , Pardi E , Borsari S , Ambrogini E , Lemmi M , Picone A , Vignali E , Viccica G , Berti P , Miccoli P , Cetani F

Familial isolated primary hyperparathyroidism (FIPH) can result either from incomplete expression of a syndromic form of familial primary hyperparathyroidism [multiple endocrine neoplasia types 1 (MEN 1), hyperparathyroidism-jaw tumor syndrome (HPT-JT), or familial hypocalciuric hypercalcemia (FHH)] or still unrecognized causes.We investigated the involvement of MEN1, HRPT2 and CASR genes by direct sequencing of germline DNA in seven...

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Endocrine Abstracts

Asymptomatic primary hyperparathyroidism: preliminary results of a prospetive randomized study on the effect of parathyroidectomy

Genetic analyses of familial isolated primary hyperparathyroidism: implications for clinical assessment and surgical management

BiosciAbstracts